Sunday, 23 December 2012

"Trojan-horse" Cancer Therapy?

In an "exciting" development in cancer research, researchers have developed a new means of delivery for cancer busting drugs. The "trojan-horse" system, still in it's laboratory phasing, is being developed by Professor Claire Lewis of the University of Sheffield. Tests thus far indicate the successes of this means of delivery, similar to the HIV virus, in which the treatment drug is transported within white blood cells.
After the treatments of radiotherapy and/or chemotherapy has concluded, the resultant damage to the tissue needs repairing, and consequently white blood cells are sent to the scene of the damage. The virally infected white blood cells at this stage have a limited number of viruses, one or two, in them. However, once they macrophages reach the site, the virus can being to replicate. Twelve hours or so later, the white blood cells burst releasing a tidal wave of ~10,000 viruses, each. A formidable force against the tumour.
Mice used in Prof Lewis's who partook in this development were "eradicated" of their cancer after 40 days. The Professor continued to remark that the research was "ground-breaking", but noted the possibility of the treatment failing to have any effect on humans. Human trials are due to start next year.
It is truly remarkable how doctors soon may be able to harness the body's own immune system to deliver targeted treatment for cancer.
Dr Kate Holmes of Head of Research at Prostate Cancer UK commented: "If this treatment goes on to be successful in human trials, it could mark substantial progress in finding better treatments for men with prostate cancer which has spread to the bone".